A Bark Disorder of Grapefruit
نویسندگان
چکیده
منابع مشابه
Management of grapefruit-drug interactions.
Grapefruit is a healthy addition to a well-balanced diet. However, the fruit has been shown to affect the metabolism of many medications, increasing the risk of toxicity and adverse effects. Characteristics of oral medications that may interact with grapefruit include extensive metabolism through the intestinal cytochrome P450 3A4 system, low bioavailability, and a narrow therapeutic index. Pro...
متن کاملA furanocoumarin-free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice-felodipine interaction.
BACKGROUND Grapefruit juice (GFJ) enhances the systemic exposure of numerous CYP3A4 drug substrates, including felodipine, by inhibiting intestinal (but not hepatic) first-pass metabolism. Furanocoumarins have been identified as major CYP3A4 inhibitors contained in the juice, but their contribution to the GFJ effect in vivo remains unclear. OBJECTIVE To ascertain whether furanocoumarins media...
متن کاملGrapefruit juice-drug interactions.
The novel finding that grapefruit juice can markedly augment oral drug bioavailability was based on an unexpected observation from an interaction study between the dihydropyridine calcium channel antagonist, felodipine, and ethanol in which grapefruit juice was used to mask the taste of the ethanol. Subsequent investigations showed that grapefruit juice acted by reducing presystemic felodipine ...
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در این تحقیق دانش زبانشناسی و کاربردشناسی زبان آموزان ایرانی در سطح بالای متوسط مقایسه شد. 50 دانش آموز با سابقه آموزشی مشابه از شش آموزشگاه زبان مختلف در دو آزمون دانش زبانشناسی و آزمون دانش گفتار شناسی زبان انگلیسی شرکت کردند که سوالات هر دو تست توسط محقق تهیه شده بود. همچنین در این تحقیق کارایی کتابهای آموزشی زبان در فراهم آوردن درون داد کافی برای زبان آموزان ایرانی به عنوان هدف جانبی تحقیق ...
15 صفحه اولEffects of Orange, Tangerine, and Grapefruit Juices on Pharmacokinetic Parameters of Cyclosporine A in Rats
This study was designed to investigate the effects of tangerine, orange, and grapefruit juice on the pharmacokinetic pattern of cyclosporine A in rats. Forty male Sprague-Dawley rats were divided into four groups to receive water, orange, tangerine, or grapefruit juices respectively. Water or juices (10 ml/kg) were given orally twice a day for 3 days. Three hours after the 5th dose, cyclosporin...
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ژورنال
عنوان ژورنال: International Organization of Citrus Virologists Conference Proceedings (1957-2010)
سال: 1965
ISSN: 0074-7203,2313-5123
DOI: 10.5070/c57wc4k0h5